“They reported decreases in depression, anxiety, and posttraumatic stress disorder symptoms; improved life satisfaction; and improved mental wellbeing.”
By Jack Gorsline, Psychedelic State(s) of America
Oregon’s state-regulated psilocybin program has maintained a strong safety record while delivering measurable mental health improvements. But an impending financial crisis threatens to dismantle the nation’s first legal psilocybin market.
A longitudinal cohort study published on Wednesday in JAMA Network Open found that supervised psilocybin sessions at licensed community wellness centers are safe and clinically effective. Yet these findings arrive as state regulators consider steep fee increases that industry insiders warn could shutter the entire system.
The Open Psychedelic Evaluation Nexus (OPEN) cohort study received federal funding from the Substance Abuse and Mental Health Services Administration (SAMHSA), the National Institutes of Health (NIH) and the National Institute on Drug Abuse (NIDA). Led by Dr. Todd Korthuis of Oregon Health & Science University, the research provides the first rigorous real-world evaluation of Oregon’s psilocybin framework.
Between November 2024 and March 2026, researchers tracked 346 clients across 24 of the state’s 26 active licensed service centers, representing 92 percent of active facilities statewide. The study retained 90.2 percent of participants at the three-month mark,
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