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THC can spark birth defects in genetically predisposed mice

Investigators from the Icahn School of Medicine at Mount Sinai are reporting that their new mice study indicates cannabis consumption during pregnancy may contribute to birth defects.

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Researchers were curious about how using cannabis — THC, in particular — could influence so-called Hedgehog signalling, in essence a “mutation that affects a mechanism that cells use to communicate with each other,” notes a news release posted on EurekAlert!

“We reasoned that THC might be an environmental risk factor for birth defects, but that it would require additional risk factors, such as specific mutations in the genes required for Hedgehog signalling, to induce these defects in mice,” Robert

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